Scientific Publications

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
Nature Biotechnology. (2018); Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen, Dylan J Drakes, Mei Song, Matthew M Miele, Zhuoning Li, Pei Wang, Su Yan, Jingyi Xiang, Xiaojing Ma, Venkatraman E Seshan, Ronald C Hendrickson, Cheng Liu & Renier J Brentjens

Development and Evaluation of an Optimal Human Single-Chain Variable Fragment-Derived BCMA-Targeted CAR T Cell Vector.
Mol Ther. 2018 Jun 6;26(6):1447-1456. doi: 10.1016/j.ymthe.2018.03.016. ; Smith EL, Staehr M, Masakayan R, Tatake IJ, Purdon TJ, Wang X, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Riviere I, Liu C, Brentjens RJ.

TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies.
JCI Insight. 2018 Feb 22;3(4). Pii; Ahmed M, Lopez-Albaitero A, Pankov D, Santich BH, Liu H, Yan S, Xiang J, Wang P, Hasan AN, Selvakumar A, O'Reilly RJ, Liu C, Cheung NV.

Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population.
Pharmacogenomics. 2017 Feb;18(3):255-264; Sun Y, Mo L, Feng X, Yang D, Tan T, Zeng L, Hui L, Wang Y, Liu C, He L.

Targeting Intracellular Antigens with pMHC-Binding Antibodies: A Phage Display Approach.
Phage Display, pages 255-269 (2017); Zhihao Wu, Brian H. Santich, Hong Liu, Cheng Liu, Nai-Kong V. Cheung

CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes.
Leukemia 31, 2254–2257. doi:10.1038/leu.2017.223 (2017); M D Mathias, J T Sockolosky, A Y Chang, K S Tan, C Liu, K C Garcia & D A Scheinberg

Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen.
Leukemia volume 31, pages 1788–1797. doi:10.1038/leu.2016.373 (2017); S Rafiq, T J Purdon, A F Daniyan, M Koneru, T Dao, C Liu, D A Scheinberg & R J Brentjens

A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens.
The Journal of Clinical Investigation. doi:110.1172/JCI92335 (2017); Aaron Y. Chang, Tao Dao, Ron S. Gejman, Casey A. Jarvis, Andrew Scott, Leonid Dubrovsky, Melissa D. Mathias, Tatyana Korontsvit, Victoriya Zakhaleva, Michael Curcio, Ronald C. Hendrickson, Cheng Liu, and David A. Scheinberg.

Targeting alpha-fetoprotein (AFP)-MHC complex with CAR T cell therapy for liver cancer.
Clinical Cancer Research. doi:10.1158/1078-0432.CCR-16-1203 (2017); Hong Liu, Yiyang Xu, Jingyi Xiang, Li Long, Shon Green, Zhiyuan Yang, Bryan Zimdahl, Jingwei Lu, Neal Cheng, Lucas H Horan, Bin Liu, Sun Yan, Pei Wang, Juan Diaz, Lu Jin,Yoko Nakano, Javier F Morales, Pengbo Zhang, Lian-xing Liu, Binnaz K Staley, Saul J Priceman, Christine E. Brown, Stephen J. Forman, Vivien W Chan, Cheng Liu.

Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity.
Oncoimmunology. 2016 Aug 3;5(9):e1211221; Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA.

Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics.
Journal of Molecular Biology. doi:10.1016/j.jmb.2015.12.002 (2015); Ataie N, Xiang J, Cheng N, Brea EJ, Lu W, Scheinberg DA, Liu C, Ng HL.

Generation of TCR-Like Antibodies Using Phage Display.
Methods Molecular Biology. doi: 10.1007/978-1-4939-2999-3_17 (2015); Santich BH, Liu H, Liu C, Cheung NK.

Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1.
Nature Biotechnology. doi: 10.1038/nbt.3349 (2015); Tao Dao, Dmitry Pankov, Andrew Scott, Tatyana Korontsvit, Victoriya Zakhaleva, Yiyang Xu, Jingyi Xiang, Su Yan, Manuel Direito de Morais Guerreiro, Nicholas Veomett, Leonid Dubrovsky, Michael Curcio, Ekaterina Doubrovina, Vladimir Ponomarev, Cheng Liu, Richard J O’Reilly & David A Scheinberg.

Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein.
Clinical Cancer Research. doi: 10.1158/1078-0432 (2014); Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O’Reilly RJ, Liu C and Scheinberg D.

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers.
Blood. 2014 124:2155; Sarwish Rafiq, Tao Dao, Cheng Liu, David A. Scheinberg and Renier J Brentjens.

Real-time cytotoxicity assays in human whole blood.
doi: 10.3791/51941 (2014); Hsiao CW, Lo YT, Liu H, Hsiao SC.

A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias.
Blood. doi: 10.1182 (2014); L. Dubrovsky, D. Pankov, E. Joseph Brea, T. Dao, A. Scott, S. Yan, R. J. O’Reilly, C. Liu and D. A. Scheinberg.

Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody.
Sci Transl Med. doi: 10.1126/scitranslmed.3005661; Dao T, Yan S, Veomett N, Pankov D, Zhou L, Korontsvit T, Scott A, Whitten J, Maslak P, Casey E, Tan T, Liu H, Zakhaleva V, Curcio M, Doubrovina E, O’Reilly RJ, Liu C, Scheinberg DA.

Reaching un-drugable intracellular targets with the long arm of antibodies.
Oncotarget. doi: 10.18632/oncotarget.1039 (2013); David A. Scheinberg, Tao Dao, Cheng Liu

Approaching untargetable tumor-associated antigens with antibodies.
Oncoimmunology. doi: 10.4161/onci.24678 (2013); Dao T, Liu C and Scheinberg DA.

Real Time Assays for Quantifying Cytotoxicity with Single Cell Resolution.
PLoS ONE. Oncoimmunology. 8(6): e66739. doi:10.1371/journal.pone.0066739 (2013); Hsiao SC, Liu H, Holstlaw TA, Liu C, Francis CY, et al.